Ketamine is a dissociative drug that has been used medically since the 1970s primarily as an anesthetic agent but also for various psychiatric applications. Anecdotal reports and clinical research suggest substantial potential for ketamine as a treatment in conjunction with psychological interventions. Here, we review historical and modern approaches to the use of ketamine with psychotherapy, discuss the clinical relevance of ketamine’s acute psychoactive effects, propose a unique model for using esketamine with Acceptance and Commitment Therapy, and suggest considerations for (...) moving medication-assisted psychotherapy forward as a field. (shrink)

ABSTRACT:While the literature on psychedelic medicine emphasizes the importance of set and setting alongside the quality of subjective drug effects for therapeutic efficacy, few scholars have explored the therapeutic frameworks that are used alongside psychedelics in the lab or in the clinic. Based on a narrative analysis of the treatment manual and post-session experience reports from a pilot study of psilocybin-assisted treatment for tobacco smoking cessation, this article examines how therapeutic frameworks interact with the psychedelic substance in ways that can (...) rapidly reshape participants' identity and sense of self. We identified multiple domains relating to identity shift that appear to serve as smoking cessation mechanisms during psilocybin sessions, each of which had an identifiable presence in the manualized treatment. As psychedelic medicine becomes mainstream, consensual and evidence-based approaches to psychedelic-assisted identity shift that respect patient autonomy and encourage empowerment should become areas of focus in the emergent field of psychedelic bioethics. (shrink)

We propose a biochemical mechanism for celiac disease and non‐celiac gluten sensitivity that may rationalize many of the extradigestive disorders not explained by the current immunogenetic model. Our hypothesis is based on the homology between the 33‐mer gliadin peptide and a component of the NMDA glutamate receptor ion channel – the human GRINA protein – using BLASTP software. Based on this homology the 33‐mer may act as a natural antagonist interfering with the normal interactions of GRINA and its partners. The (...) theory is supported by numerous independent data from the literature, and provides a mechanistic link with otherwise unrelated disorders, such as cleft lip and palate, thyroid dysfunction, restless legs syndrome, depression, ataxia, hearing loss, fibromyalgia, dermatitis herpetiformis, schizophrenia, toxoplasmosis, anemia, osteopenia, Fabry disease, Barret's adenocarcinoma, neuroblastoma, urinary incontinence, recurrent miscarriage, cardiac anomalies, reduced risk of breast cancer, stiff person syndrome, etc. The hypothesis also anticipates better animal models, and has the potential to open new avenues of research. (shrink)

The use of the circle to signify wine was common medieval logicians. The author of this article studies the true sense in which those masters used it, making use of literature and the work of great logicians, such as Albert of Saxony and William of Ockham, to do so.

This article examines the account of the relationship between sin and suffering provided by J. L. A. Garcia in “Sin and Suffering in a Catholic Understanding of Medical Ethics,” in this issue. Garcia draws on the (Roman) Catholic tradition and particularly on the thought of Thomas Aquinas, who remains an important resource for Catholic theology. Nevertheless, his interpretation of Thomas is open to criticism, both in terms of omissions and in terms of positive claims. Garcia includes those (...) elements of Thomas that are purely philosophical, such as natural law and acquired virtue, but neglects the theological and infused virtues, the gifts and fruits of the Holy Spirit, and the beatitudes. These omissions distort his account of the Christian life so that he underplays both the radical problem posed by sin (and suffering), and the radical character of the ultimate solution: redemption in Christ through the grace of the Holy Spirit. (shrink)

El presente texto ofrece un examen sobre la correspondencia que existe entre el deterioro moral y el comportamiento hostil. Con este propósito, la reflexión transita por la querella de carácter ético que tiene lugar en La peste de Albert Camus y por el desvelamiento de una violencia contemporánea que se viste bajo el aspecto de una apremiante autoafirmación de sí, un destape que Byung-Chul Han lleva a cabo en su Topología de la violencia. La llamada que ambos autores lanzan (...) sobre la disposición del espíritu humano que resulta capaz de confirmar este sombrío vínculo o de emanciparnos de él, se convierte en un cometido ante el que el juicio crítico necesita responder. (shrink)

La realización del sí mismo representa un cometido que interpela a nuestra propia identidad humana. La heterogeneidad y riqueza de las voces que hablan sobre el cómo responder a ello demandan una deliberación atenta y mesurada. Para algunos, esta tarea supone un alto costo intersubjetivo que eventualmente nos vemos orillados a pagar. Para otros, es apremiante establecer un límite a tal importe para, precisamente, salvaguardar al sí mismo. En esta escena, la propuesta reflexiva de Albert Camus nos ofrece un (...) sensato balance que nos permite situar las coordenadas en las que la conducción de la particular existencia se traduce en una realización compartida. (shrink)

El pensamiento filosófico de Camus coloca al tema de la vida y su sentido en el centro de toda reflexión pertinente para el existir humano. Efectivamente, la vida y lo que hace de ella un suceso valioso ocupa al entendimiento para responder ante los hechos que parecen reducir la existencia humana a un evento inquietantemente insignificante. Esto es precisamente lo que produce la experiencia de lo absurdo, cuyo proceder comporta un aspecto deshumanizador que logra ponerse de manifiesto a través de (...) acontecimientos muy puntuales que alertan y miden el alcance de nuestra comprensión. En Camus, la referencia a vivencias como la del totalitarismo moderno advierten un modo peculiar, y hasta entonces desconocido, de violentar la vida humana hasta un punto en el que, frente a lo descabellado de los hechos, el pensamiento queda como acallado. No obstante, el juicio crítico se vuelve más urgente, sobre todo, cuando notamos que la psicología que subyace a estas prácticas se reproduce en nuestra época bajo otras formas igual de brutales y preocupantemente alarmantes, como lo es el caso de la tortura institucionalizada. En este sentido, es posible que la crítica de Camus sea tan efectiva ahora como en su tiempo, particularmente, cuando la práctica de la vida comporta un aspecto hostil que a la vez pone a prueba a nuestro discernimiento y a nuestra capacidad de coexistir. (shrink)

La tarea que supone elaborarse a sí mismo conlleva un desafío que constantemente nos pone a prueba, pero cuando el costo de este cometido se deposita en la espalda de alguien más, hasta desvalorizarlo, menoscabarlo y anularlo, tiene lugar la inquietante experiencia de la humillación. El presente texto se propone indagar sobre esta manera de proceder, en la que un deformado anhelo de la consecución de sí reclama la humillación del otro. De la mano de Albert Camus, Cornelius Castoriadis (...) y Richard Rorty, el trabajo ofrece una mirada que insiste en el mérito de una constitución de sí sin disminuir al otro, pues, ante una escena de esta naturaleza, el juicio crítico se ve comprometido a dar una respuesta que sea capaz de reivindicar el valor de nuestra condición humana, frente a las iniciativas que pretenden desestimarla. (shrink)

La riqueza de una dimensión humana como la libertad merece el compromiso de cuidar de ella, y nuestra manera de atender a esta tarea pone a prueba el valor que le conferimos a nuestro propio ser. El pasar por alto este cometido se traduce en una experiencia de atropello, que termina por enrolarnos a todos en un interminable ciclo de hostilidad. Albert Camus nos ofrece una mirada que nos permite reconocer el mérito de ocuparnos de nuestro ser libre, sin (...) atribuirle a nuestra libertad un carácter absoluto bajo el que se esconde la intención de obtener un provecho sobre los demás. De manera que nuestra libertad se realiza en la medida en que nos proporciona un bien que no es monopolio de ninguno, al contrario, beneficia a cada quién en tanto que lo hemos alcanzado en conjunto. (shrink)

The Averroistic Monopsychism could not be incorporated to the Christian thought to darken the idea of the immortality of the personal soul. Albert the Great, tries to make a synthesis of the Arab doctrines and the Doctrine of Divine Illumination. The conclusion is a proposal -not systematize- but where it is possible to found the distinction at personal level between intellect agent and possible intellect, in analogous way to the distinction essence/act of being.

Die MISCELLANEA MEDIAEVALIA präsentieren seit ihrer Gründung durch Paul Wilpert im Jahre 1962 Arbeiten des Thomas-Instituts der Universität zu Köln. Das Kernstück der Publikationsreihe bilden die Akten der im zweijährigen Rhythmus stattfindenden Kölner Mediaevistentagungen, die vor über 50 Jahren von Josef Koch, dem Gründungsdirektor des Instituts, ins Leben gerufen wurden. Der interdisziplinäre Charakter dieser Kongresse prägt auch die Tagungsakten: Die MISCELLANEA MEDIAEVALIA versammeln Beiträge aus allen mediävistischen Disziplinen - die mittelalterliche Geschichte, die Philosophie, die Theologie sowie die Kunst- und Literaturwissenschaften (...) sind Teile einer Gesamtbetrachtung des Mittelalters. (shrink)

This book is an attempt to get to the bottom of an acute and perennial tension between our best scientific pictures of the fundamental physical structure of the world and our everyday empirical experience of it. The trouble is about the direction of time. The situation (very briefly) is that it is a consequence of almost every one of those fundamental scientific pictures--and that it is at the same time radically at odds with our common sense--that whatever can happen can (...) just as naturally happen backwards. Albert provides an unprecedentedly clear, lively, and systematic new account--in the context of a Newtonian-Mechanical picture of the world--of the ultimate origins of the statistical regularities we see around us, of the temporal irreversibility of the Second Law of Thermodynamics, of the asymmetries in our epistemic access to the past and the future, and of our conviction that by acting now we can affect the future but not the past. Then, in the final section of the book, he generalizes the Newtonian picture to the quantum-mechanical case and (most interestingly) suggests a very deep potential connection between the problem of the direction of time and the quantum-mechanical measurement problem. The book aims to be both an original contribution to the present scientific and philosophical understanding of these matters at the most advanced level, and something in the nature of an elementary textbook on the subject accessible to interested high-school students. Table of Contents: Preface 1. Time-Reversal Invariance 2. Thermodynamics 3. Statistical Mechanics 4. The Reversibility Objections and the Past-Hypothesis 5. The Scope of Thermodynamics 6. The Asymmetries of Knowledge and Intervention 7. Quantum Mechanics Appendix: Gedankenexperiments with Heat Engines Index Reviews of this book: The foundations of statistical mechanisms are often presented in physics textbooks in a rather obscure and confused way. By challenging common ways of thinking about this subject, Time and Chance can do quite a lot to improve this situation. --Jean Bricmont, Science Albert is perfecting a style of foundational analysis that is uniquely his own...It has a surgical precision...and it is ruthless with pretensions. The foundations of thermodynamics is a topic that has accumulated a good deal of dead wood; this is a fire that will burn and burn. --Simon W. Saunders, Oxford University As usual with Albert's work, the exposition is brisk and to the point, and exceptionally clear...The book will be an extremely valuable contribution to the literature on the subject of philosophical issues in thermodynamics and statistical mechanics, a literature which has been thin on the ground but is now growing as it deserves to. --Lawrence Sklar, University of Michigan. (shrink)

Die MISCELLANEA MEDIAEVALIA präsentieren seit ihrer Gründung durch Paul Wilpert im Jahre 1962 Arbeiten des Thomas-Instituts der Universität zu Köln. Das Kernstück der Publikationsreihe bilden die Akten der im zweijährigen Rhythmus stattfindenden Kölner Mediaevistentagungen, die vor über 50 Jahren von Josef Koch, dem Gründungsdirektor des Instituts, ins Leben gerufen wurden. Der interdisziplinäre Charakter dieser Kongresse prägt auch die Tagungsakten: Die MISCELLANEA MEDIAEVALIA versammeln Beiträge aus allen mediävistischen Disziplinen - die mittelalterliche Geschichte, die Philosophie, die Theologie sowie die Kunst- und Literaturwissenschaften (...) sind Teile einer Gesamtbetrachtung des Mittelalters. (shrink)

The most interesting biological molecules are long polymers. In analogy with human alphabetic languages, they can be called texts and analysed, as to the primary structure, as sequences of letters or of words . It is considered that the study of words, in a linguistic approach, may contribute positively to the understanding of molecular interactions . The molecular and human languages and dialects are contrasted. The molecular one is peculiarly distinct from the human, for instance, by its use of a (...) tridimensional morphology, temporal dynamics, absence of spacings and punctuation, and overlapping messages. A mathematical method is presented, for discovering words in texts. The word AAA was studied in the evolution of the 5S ribosomal RNA. It was shown that this word is more frequent in less complex organisms and less frequent in the more complex ones, in the fungi, plants, and vertebrates lineages. In the two latter ones, the degree of genie variability was also reduced. To the contrary, a moderate degree of usage of this word persisted in the whole invertebrates lineage, where a high degree of genie variability was maintained. In mitochondria, plastids and mycoplasmas, the frequency of the word AAA was increased, consistently with their need for interactions with a wider range of variation. These behaviors indicate that the monotonous AAA word allows for ambiguity in interactions. With the evolution of organic complexity and of greater molecular specificity, ambiguous words were progressively avoided.As moléculas biológicas mais interessantes são longos polímeros. Em analogia com a linguagem humana alfabética, estes podem ser chamados de textos, e analisados, quanto à estrutura primária, como sequência de letras ou de palavras . Considera-se que o estudo das palavras, em abordagem de tipo lingüístico, possa contribuir para o entendimento das interações moleculares. As linguagens e dialetos, moleculares e humanos, são contrastados. A linguagem molecular se distingue peculiarmente da humana, por exemplo, por utilizar forma tridimensional, dinâmica temporal, ausência de espaçamento e pontuação, e sobreposição de significados. Apresenta-se um método matemático para descoberta, de palavras em textos. A palavra AAA foi estudada na evolução do RNA ribossômico 5S. Observou-se que esta palavra é mais freqüente em organismos menos complexos e menos freqüente nos mais complexos, das linhagens de fungos, plantas e vertebrados. Nas duas últimas, reduziu-se também o grau de variabilidade gênica. Pelo contrário, grau moderado de freqüência da palavra persistiu em toda a linhagem dos invertebrados, com manutenção paralela de alto nível de variabilidade gênica. Nas mitocôndrias, plastídeos e micoplasmas, a freqüência da palavra AAA foi aumentada, de acordo com sua necessidade de interações com maior amplitude de variação. Esses comportamentos indicam que a palavra monótona AAA permite ambigüidade de interações. Com a evolução da complexidade orgânica e da maior especificidade molecular, as palavras ambíguas foram progressivamente evitadas. (shrink)

This article aims to revisit the second essay of Nietzsche’s Genealogy of Morals, in order to show some aesthetic-theoretical assumptions present in his genealogical investigation on memory and suffering. Central to the purposes of this analysis is Homer’s role, more precisely, the artistic strategies and procedures of his poetics.

Explora-se o conceito de que a diversidade propicia robutez nos sistemas processadores de informação e como seria aplicável às areas neurais e sociais, incluindo o fenômeno religioso. Avaliação de estatísticas populacionais indica que o último não é essencial ao humano, apesar de ser praticamente constante nas culturas. Discutem-se os aspectos cognitivos e afetivos na ciência e na religião, sob a proposta de que demarcação adequada pode auxiliar na redução de conflitos. Nesse mesmo sentido pode contribuir a elaboração sobre as tensões (...) entre verdades – determinismos – e liberdades, que decorreriam do uso dos conceitos de crenças fortes e fracas, ou seja, entre crenças e hipóteses que parecem promissoras – merecedoras de créditos de confiança. Indica-se a possibilidade de se considerar um sistema de culturas distintas e diversas, apesar das tendências globalizadoras que podem incidir sobre os aspectos mais materiais. Palavras-chave : Estabilidade; Sistema; Evolução; Biologia; Sociedade; Cognição; Afetividade; Essência; Transcendência; Hipótese; Verdade.The concept that diversity propitiates robustness in information processing systems is explored and indicated to be applicable in the neural and social areas, including the religious phenomenon. Evaluation of statistics in populations indicates that the latter is not essential to the human, in spite of being a constant among cultures. Cognitive and affective aspects in science and religion are discussed under the proposition that adequate demarcation may help in reducing conflicts. Elaboration on the tensions between truths – deterministic – and freedom may contribute in the same direction. Tensions may arise from the utilization of the concepts of strong and weak concepts of belief, that is, between beliefs and seemingly fruitful hypotheses – deserving credits of trustfulness. The possibility of considering a system of distinct and diverse cultures is indicated, in spite of the globalizing tendencies that may prevail over other more material aspects. Key words : Stability; System; Evolution; Biology; Society; Cognition; Affection; Essence; Transcendence; Hypothesis; Truth. (shrink)

ABSTRACT This article reviews the book Ayn Rand e il fascismo eterno. Una narrazione distopica, by Diana Thermes. This is the first Italian book specifically devoted to Rand’s thought and novels. Thermes has conducted her study in a remarkably original way, profusely interrelating Rand’s fiction works with the long-standing tradition of dystopian literature and her analysis of collectivism with the most significant contributions on the nature and causes of totalitarianism, as well as illustrating the relevance of Rand’s ideas in the (...) face of present-day challenges. (shrink)

ABSTRACT The purpose of the present article is to provide a comparative introduction to Ayn Rand’s philosophy of Objectivism by exploring her most significant intellectual interactions with some of the leading figures of the libertarian movement. While revolving around Ludwig von Mises, Friedrich Hayek, Murray Rothbard, and Robert Nozick, it nevertheless pays attention to Rand’s and Objectivism’s relationship, affinities, and differences with additional authors belonging to this tradition.

The responses of 178 Latin dioceses in the United States Conference of Catholic Bishops (USCCB) to the Preparatory Document for the Synod on Synodality were synthesized in fourteen regional reports. From these reports, and a report of lay groups, the USCCB produced the US report, which was synthesized with 111 other national reports into the Working Document for the Continental Stage (DCS). The latter was provided to seven continental assemblies. North American participants discussed the DCS in virtual meetings, and a (...) writing team produced the North American report. The synthesized result of the continental assemblies’ reports was the synod’s 2023 Instrumentum laboris. This article discusses US diocesan participation and the North American response to the DCS as they contributed to the Instrumentum laboris’ statement relative to “the question of women’s inclusion in the diaconate.” It includes a table documenting US diocesan responses to questions of women’s participation in the Church. (shrink)

From the author of Quantum Mechanics and Experience, a hugely influential book that challenged key assertions by Niels Bohr and other founders of quantum mechanics, A Guess at the Riddle provides a major metaphysical overhaul of one of physics' most intractable problems-the quest to bridge quantum and classical physics in order to understand the nature of reality.

Online Public Shaming is a form of norm enforcement that involves collectively imposing reputational costs on a person for having a certain kind of moral character. OPS actions aim to disqualify her from public discussion and certain normal human relations. We argue that this constitutes an informal collective punishment that it is presumptively wrong to impose on others. OPS functions as a form of ostracism that fails to show equal basic respect to its targets. Additionally, in seeking to mobilise unconstrained (...) collective power with potentially serious punitive consequences, OPS is incompatible with due process values. (shrink)

The article aims to revisit the relationship between inequality and education, a theme that accompanies education in modern societies. Despite access to data on inequality in society and education, as well as many analyzes of the origins and trends that provoke real social apartheids one has the impression that the metaphor of the labyrinth, common in Latin American literature, applies to education. The article is divided in two parts. The first seeks to situate the theme of inequality as a problem (...) of education and for education, with a brief reference to classic works and the identification of some pedagogical places that can serve to perpetuate inequality or resist it. The second part, based on thoughts from the beginning of the second half of the last century, revolves around the question of whether we are facing yet another unfinished revolution in Latin America. Two themes are discussed: updating the notion of awareness and the pedagogical nuances of concepts such as liberation, social exclusion and coloniality. In the conclusion, Paulo Freire’s centrality is emphasized to understand the relationship between inequality and education, and to create untested feasibilities in education and through education to promote a less unequal and more just society. Keywords: Inequality. Democracy. Awareness. Liberation. coloniality. (shrink)

A obra aborda dois específicos temas - a ética e a utopia em sua relação com a educação. Os textos aqui apresentados sinalizam temas novos a serem explorados e outros nem tão novos a serem revisitados para que possa haver novos avanços, para além de Paulo Freire.